Quantification of Knee Cartilage In Vivo In the MMT Model of Osteoarthritis in Rats Using MRI
نویسندگان
چکیده
Introduction Preclinical drug development in the area of osteoarthritis (OA) requires robust and reliable assessment of disease progression. The morphology of the articular cartilage is considered to be the primary marker of OA progression. However, the challenges of small animal in-vivo imaging and image analysis have limited the use of MRI in preclinical OA research. We present an approach for the quantification of rat knee cartilage volume and surface area in the medial meniscal tear (MMT) model of OA [1].
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